The Vampire Lestat goes on tour while being haunted by "muses" from his past. As the band's popularity grows, so does Lestat's influence over vampires & humans alike, leaving others to contend with Lestat's power in the face of the Great Conversion.

En 2022, le vampire Louis de Pointe du Lac raconte son histoire au célèbre journaliste Daniel Molloy. En 1910 à La Nouvelle-Orléans, Louis et Lestat forment une famille vampirique à laquelle vient s'ajouter Claudia, la novice adolescente.